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skos:definition |
MSH: An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.,NCI: Encoded by human ALOX15 Gene, a putative mutator gene regulated by tumor-suppressor TP53, 661-amino acid 74.7 kD cytoplasmic Arachidonate 15-Lipoxygenase (Lipoxygenase Family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis. It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid. (OMIM, Swiss-Prot, and NCI)
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