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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.,CSP: antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis.,PDQ: A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0066610,
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umls-concept:C0208855,
umls-concept:C0622246,
umls-concept:C0645926,
umls-concept:C0702048,
umls-concept:C0702049,
umls-concept:C0702050,
umls-concept:C0702051,
umls-concept:C0731115,
umls-concept:C1176160,
umls-concept:C1522440,
umls-concept:C1530103
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skos-xl:prefLabel |
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skos-xl:altLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112186147,
http://linkedlifedata.com/resource/umls/relation/R32104170,
http://linkedlifedata.com/resource/umls/relation/R32104172,
http://linkedlifedata.com/resource/umls/relation/R32104173,
http://linkedlifedata.com/resource/umls/relation/R32104171,
http://linkedlifedata.com/resource/umls/relation/R120529377,
http://linkedlifedata.com/resource/umls/relation/R120529378,
http://linkedlifedata.com/resource/umls/relation/R120529380,
http://linkedlifedata.com/resource/umls/relation/R120529381,
http://linkedlifedata.com/resource/umls/relation/R120529382,
http://linkedlifedata.com/resource/umls/relation/R120529383,
http://linkedlifedata.com/resource/umls/relation/R120529384,
http://linkedlifedata.com/resource/umls/relation/R120529385,
http://linkedlifedata.com/resource/umls/relation/R120529386,
http://linkedlifedata.com/resource/umls/relation/R120529387,
http://linkedlifedata.com/resource/umls/relation/R120529388,
http://linkedlifedata.com/resource/umls/relation/R120529390,
http://linkedlifedata.com/resource/umls/relation/R120529391,
http://linkedlifedata.com/resource/umls/relation/R120529392,
http://linkedlifedata.com/resource/umls/relation/R120529394,
http://linkedlifedata.com/resource/umls/relation/R120529395,
http://linkedlifedata.com/resource/umls/relation/R120529396,
http://linkedlifedata.com/resource/umls/relation/R120529397,
http://linkedlifedata.com/resource/umls/relation/R120529398
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