|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0026837,
umls-concept:C0037949,
umls-concept:C0085983,
umls-concept:C0086418,
umls-concept:C0184511,
umls-concept:C0205217,
umls-concept:C0220781,
umls-concept:C0332282,
umls-concept:C0441655,
umls-concept:C1511636,
umls-concept:C1521991,
umls-concept:C1553027,
umls-concept:C1883254
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|
pubmed:issue |
20
|
|
pubmed:dateCreated |
1999-2-2
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|
pubmed:abstractText |
Cis-Octahydro-14H-benzo[g]quinolino[2,3-a]quinolidines 6 were obtained in 6 steps from L-phenylalanine. The key step utilizes a diastereoselective intramolecular EtAlCl2-catalyzed hetero-Diels-Alder reaction. Compounds 6a-f were tested in vitro against human medulloblastoma D283 Med and glioblastoma A-172 and T98G cell lines and showed improved cytotoxicity compared to the corresponding, less rigid pyrido[1,2-b]isoquinolines 1.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
|
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pubmed:volume |
8
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2881-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9873641-Antineoplastic Agents,
pubmed-meshheading:9873641-Brain Neoplasms,
pubmed-meshheading:9873641-Cell Line,
pubmed-meshheading:9873641-Drug Screening Assays, Antitumor,
pubmed-meshheading:9873641-Humans,
pubmed-meshheading:9873641-Inhibitory Concentration 50,
pubmed-meshheading:9873641-Quinolines,
pubmed-meshheading:9873641-Structure-Activity Relationship,
pubmed-meshheading:9873641-Tumor Cells, Cultured
|
|
pubmed:year |
1998
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|
pubmed:articleTitle |
Diastereoselective synthesis of octahydro-14H-benzo[g]quinolino-[2,3-a]quinolidines. Improved cytotoxic activity against human brain tumor cell lines as a result of the increased rigidity of the molecular backbone.
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|
pubmed:affiliation |
Institut für Organische Chemie der Technischen Universität Braunschweig, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
