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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1999-2-1
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pubmed:abstractText |
The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libraries of compounds that mimic the beta-strand secondary structure of proteins. Several potent and selective inhibitors of proteases have been discovered.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Chymases,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Kallikreins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Library,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptases,
http://linkedlifedata.com/resource/pubmed/chemical/chymase 2
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BabuSS,
pubmed-author:BlaskovichM AMA,
pubmed-author:BoatmanP DPD,
pubmed-author:CauDD,
pubmed-author:FergusonM DMD,
pubmed-author:GallAA,
pubmed-author:KahnMM,
pubmed-author:LittleTT,
pubmed-author:MearaJ PJP,
pubmed-author:MinarikRR,
pubmed-author:NakanishiHH,
pubmed-author:NelsonSS,
pubmed-author:NguyenMM,
pubmed-author:OkeyII,
pubmed-author:QabarM NMN,
pubmed-author:RuanFF,
pubmed-author:TulinskyJJ,
pubmed-author:UrbanJJ,
pubmed-author:WUL MLM
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2321-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9873535-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:9873535-Chymases,
pubmed-meshheading:9873535-Indicators and Reagents,
pubmed-meshheading:9873535-Kallikreins,
pubmed-meshheading:9873535-Kinetics,
pubmed-meshheading:9873535-Models, Molecular,
pubmed-meshheading:9873535-Peptide Library,
pubmed-meshheading:9873535-Protease Inhibitors,
pubmed-meshheading:9873535-Protein Structure, Secondary,
pubmed-meshheading:9873535-Serine Endopeptidases,
pubmed-meshheading:9873535-Serine Proteinase Inhibitors,
pubmed-meshheading:9873535-Structure-Activity Relationship,
pubmed-meshheading:9873535-Thrombin,
pubmed-meshheading:9873535-Trypsin Inhibitors,
pubmed-meshheading:9873535-Tryptases
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pubmed:year |
1998
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pubmed:articleTitle |
Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics.
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pubmed:affiliation |
Molecumetics Ltd., Bellevue, WA 98005-2199, USA.
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pubmed:publicationType |
Journal Article
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