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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1999-1-14
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pubmed:abstractText |
Chimeric T84.66 (cT84.66) is a high-affinity (1.16x10(11) M(-1)) IgG1 monoclonal antibody against carcinoembryonic antigen (CEA). The purpose of this pilot trial was to evaluate the tumor-targeting properties, biodistribution, pharmacokinetics and immunogenicity of 111In-labeled cT84.66 as a function of administered antibody protein dose.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0161-5505
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pubmed:author |
pubmed-author:BeattyJ DJD,
pubmed-author:ChuD ZDZ,
pubmed-author:EstebanJ MJM,
pubmed-author:LipJJ,
pubmed-author:Odom-MaryonT LTL,
pubmed-author:PrimusF JFJ,
pubmed-author:RaubitschekA AAA,
pubmed-author:ShivelyJ EJE,
pubmed-author:WilliamsL ELE,
pubmed-author:WongJ YJY,
pubmed-author:WuA MAM,
pubmed-author:YamauchiDD
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2097-104
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9867150-Adult,
pubmed-meshheading:9867150-Aged,
pubmed-meshheading:9867150-Animals,
pubmed-meshheading:9867150-Antibodies, Monoclonal,
pubmed-meshheading:9867150-Carcinoembryonic Antigen,
pubmed-meshheading:9867150-Colorectal Neoplasms,
pubmed-meshheading:9867150-Female,
pubmed-meshheading:9867150-Humans,
pubmed-meshheading:9867150-Immunoglobulin G,
pubmed-meshheading:9867150-Indium Radioisotopes,
pubmed-meshheading:9867150-Liver Neoplasms,
pubmed-meshheading:9867150-Lymphatic Metastasis,
pubmed-meshheading:9867150-Male,
pubmed-meshheading:9867150-Metabolic Clearance Rate,
pubmed-meshheading:9867150-Mice,
pubmed-meshheading:9867150-Middle Aged,
pubmed-meshheading:9867150-Neoplasm Metastasis,
pubmed-meshheading:9867150-Pilot Projects,
pubmed-meshheading:9867150-Radioimmunotherapy,
pubmed-meshheading:9867150-Radiopharmaceuticals,
pubmed-meshheading:9867150-Radiotherapy, Adjuvant,
pubmed-meshheading:9867150-Radiotherapy Dosage,
pubmed-meshheading:9867150-Sensitivity and Specificity,
pubmed-meshheading:9867150-Tissue Distribution
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pubmed:year |
1998
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pubmed:articleTitle |
Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients.
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pubmed:affiliation |
Division of Radiation Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
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