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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0024264,
umls-concept:C0085358,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2911684
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pubmed:issue |
11
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pubmed:dateCreated |
1998-11-5
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pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8(+) lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-1532395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-1567573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-1671109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-1910679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-2162180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-2184033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-2331748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-2656013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-7584111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-7585150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-7666531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-7727764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-7904901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-7970995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8113679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8575199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8603993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8629022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8649511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8649512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8674119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8697627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8709256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8713658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8764060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8782755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8826814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8941225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-8946685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9050826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9050881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9092480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9151905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9203422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9207008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9223457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9230427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9261420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9461179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9501224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9525642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9765450-9529330
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9054-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9765450-Humans,
pubmed-meshheading:9765450-Fetus,
pubmed-meshheading:9765450-Child,
pubmed-meshheading:9765450-Infant, Newborn,
pubmed-meshheading:9765450-Adult,
pubmed-meshheading:9765450-Cells, Cultured,
pubmed-meshheading:9765450-Phenotype,
pubmed-meshheading:9765450-Lymphocyte Activation,
pubmed-meshheading:9765450-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:9765450-T-Lymphocyte Subsets,
pubmed-meshheading:9765450-Antigens, CD45,
pubmed-meshheading:9765450-HIV-1,
pubmed-meshheading:9765450-HIV Infections,
pubmed-meshheading:9765450-Receptors, HIV,
pubmed-meshheading:9765450-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:9765450-Antigens, CD4,
pubmed-meshheading:9765450-CD8-Positive T-Lymphocytes
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