Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-8-25
pubmed:abstractText
Mutations in the low density lipoprotein (LDL) receptor gene cause familial hypercholesterolemia, a human disease characterized by premature atherosclerosis and markedly elevated plasma levels of LDL cholesterol and apolipoprotein (apo) B100. In contrast, mice deficient for the LDL receptor (Ldlr-/-) have only mildly elevated LDL cholesterol levels and little atherosclerosis. This difference results from extensive editing of the hepatic apoB mRNA in the mouse, which limits apoB100 synthesis in favor of apoB48 synthesis. We have generated Ldlr-/- mice that cannot edit the apoB mRNA and therefore synthesize exclusively apoB100. These mice had markedly elevated LDL cholesterol and apoB100 levels and developed extensive atherosclerosis on a chow diet. This authentic model of human familial hypercholesterolemia will provide a new tool for studying atherosclerosis.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1078-8956
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
934-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9701246-Animals, pubmed-meshheading:9701246-Aorta, Thoracic, pubmed-meshheading:9701246-Apolipoproteins B, pubmed-meshheading:9701246-Arteriosclerosis, pubmed-meshheading:9701246-Cholesterol, pubmed-meshheading:9701246-Cholesterol, LDL, pubmed-meshheading:9701246-Crosses, Genetic, pubmed-meshheading:9701246-Diet, Fat-Restricted, pubmed-meshheading:9701246-Disease Models, Animal, pubmed-meshheading:9701246-Female, pubmed-meshheading:9701246-Humans, pubmed-meshheading:9701246-Hyperlipoproteinemia Type II, pubmed-meshheading:9701246-Liver, pubmed-meshheading:9701246-Male, pubmed-meshheading:9701246-Mice, pubmed-meshheading:9701246-Mice, Knockout, pubmed-meshheading:9701246-Muscle, Smooth, Vascular, pubmed-meshheading:9701246-RNA, Messenger, pubmed-meshheading:9701246-RNA Editing, pubmed-meshheading:9701246-Receptors, LDL, pubmed-meshheading:9701246-Sex Characteristics, pubmed-meshheading:9701246-Triglycerides
pubmed:year
1998
pubmed:articleTitle
A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.
pubmed:affiliation
Cardiovascular Research, Genentech Inc., South San Francisco, California 94080, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.