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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-9-29
|
| pubmed:abstractText |
Certain beta-carbolines are known to be hallucinogenic in humans, and several produce stimulus effects in animals similar to those of the classical hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM). Classical hallucinogens bind at 5-HT2 serotonin receptors and these receptors are thought to play a role in their mechanism of action. In the present study, we examined the binding of 15 beta-carbolines at rat 5-HT2A and 5-HT2C receptors. Affinities (Ki values) of the beta-carbolines ranged from about 100 nM to greater than 10,000 nM depending upon the degree of saturation of the pyridyl ring, and upon the presence and location of methoxy substituents in the benzenoid ring. In a further study, six rats were trained to discriminate the hallucinogenic beta-carboline harmaline (3.0 mg/kg, i.p.) from vehicle using a VI-15s schedule of reinforcement. This represents the first time a hallucinogenic beta-carboline has been used as a training drug in a drug discrimination study. Administration of DOM to the harmaline-trained animals resulted in 76% harmaline-appropriate responding at 1.25 mg/kg DOM and disruption of behavior at a higher dose. Taken together, the results of the present investigation demonstrate that: (a) certain beta-carbolines bind at 5-HT2 receptors; (b) that harmaline serves as a training drug at 3.0 mg/kg in drug discrimination studies with rats as subjects; and that (c) there is some similarity between the stimulus effects produced by harmaline and DOM.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,5-Dimethoxy-4-Methylamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Carbolines,
http://linkedlifedata.com/resource/pubmed/chemical/Hallucinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Harmaline,
http://linkedlifedata.com/resource/pubmed/chemical/Harmine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0376-8716
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
99-107
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9649961-2,5-Dimethoxy-4-Methylamphetamine,
pubmed-meshheading:9649961-Animals,
pubmed-meshheading:9649961-Carbolines,
pubmed-meshheading:9649961-Conditioning, Operant,
pubmed-meshheading:9649961-Confidence Intervals,
pubmed-meshheading:9649961-Cues,
pubmed-meshheading:9649961-Discrimination Learning,
pubmed-meshheading:9649961-Dose-Response Relationship, Drug,
pubmed-meshheading:9649961-Generalization, Stimulus,
pubmed-meshheading:9649961-Hallucinogens,
pubmed-meshheading:9649961-Harmaline,
pubmed-meshheading:9649961-Harmine,
pubmed-meshheading:9649961-Male,
pubmed-meshheading:9649961-Rats,
pubmed-meshheading:9649961-Rats, Sprague-Dawley,
pubmed-meshheading:9649961-Receptors, Serotonin,
pubmed-meshheading:9649961-Serotonin Receptor Agonists,
pubmed-meshheading:9649961-Structure-Activity Relationship,
pubmed-meshheading:9649961-Time Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Investigation of hallucinogenic and related beta-carbolines.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia Campus/Virginia Commonwealth University, Richmond 23298-0540, USA.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|