rdf:type |
|
lifeskim:mentions |
umls-concept:C0007137,
umls-concept:C0017681,
umls-concept:C0023078,
umls-concept:C0030705,
umls-concept:C0038952,
umls-concept:C0080055,
umls-concept:C0205276,
umls-concept:C0332293,
umls-concept:C0681842,
umls-concept:C1514559,
umls-concept:C1522449,
umls-concept:C1947913,
umls-concept:C2587213
|
pubmed:issue |
1
|
pubmed:dateCreated |
1998-5-19
|
pubmed:abstractText |
Nonfunctional or mutated p53 protein (m-p53) is found in a myriad of solid tumors in humans. m-p53 is believed to confer radioresistance through inhibition of radiation-induced apoptosis. This study was carried out to determine if the overexpression of p53 in squamous cell carcinomas (SCC) of the glottic larynx treated with radiation therapy alone carried a poorer prognosis than normal wild-type p53 (w-p53) and could, therefore, be used as a marker of radioresistance in glottic SCC.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0360-3016
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
41
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
37-42
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:9588915-Adult,
pubmed-meshheading:9588915-Aged,
pubmed-meshheading:9588915-Aged, 80 and over,
pubmed-meshheading:9588915-Carcinoma, Squamous Cell,
pubmed-meshheading:9588915-Disease-Free Survival,
pubmed-meshheading:9588915-Female,
pubmed-meshheading:9588915-Glottis,
pubmed-meshheading:9588915-Humans,
pubmed-meshheading:9588915-Laryngeal Neoplasms,
pubmed-meshheading:9588915-Male,
pubmed-meshheading:9588915-Middle Aged,
pubmed-meshheading:9588915-Multivariate Analysis,
pubmed-meshheading:9588915-Neoplasm Proteins,
pubmed-meshheading:9588915-Neoplasm Staging,
pubmed-meshheading:9588915-Prognosis,
pubmed-meshheading:9588915-Tumor Suppressor Protein p53
|
pubmed:year |
1998
|
pubmed:articleTitle |
Overexpression of p53 protein does not predict local-regional control or survival in patients with early-stage squamous cell carcinoma of the glottic larynx treated with radiotherapy.
|
pubmed:affiliation |
Department of Radiation Oncology, McGill University, Montreal, Quebec, Canada.
|
pubmed:publicationType |
Journal Article,
Review
|