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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1998-6-9
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pubmed:abstractText |
Long term use of topical drugs has clearly been shown to induce toxic immunopathological changes in the ocular surface. However, little is known concerning the respective roles of active compounds and preservatives. Benzalkonium chloride (BAC) is the most used preservative and its cytotoxicity is well known, but other preservatives have not yet been clearly evaluated. We thus performed a comparative study to investigate toxic side effects induced in the rat ocular surface by applications of various preservatives, with special attention to inflammatory infiltrates.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0271-3683
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-25
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9561834-Animals,
pubmed-meshheading:9561834-Conjunctiva,
pubmed-meshheading:9561834-Cornea,
pubmed-meshheading:9561834-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:9561834-Histocompatibility Antigens Class II,
pubmed-meshheading:9561834-Immunity, Cellular,
pubmed-meshheading:9561834-Male,
pubmed-meshheading:9561834-Ophthalmic Solutions,
pubmed-meshheading:9561834-Rats,
pubmed-meshheading:9561834-Tissue Preservation
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pubmed:year |
1998
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pubmed:articleTitle |
Histopathological effects of topical ophthalmic preservatives on rat corneoconjunctival surface.
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pubmed:affiliation |
Department of Ophthalmology, ERCA INSERM, Ambroise Paré Hospital, University of Paris V, Boulogne, France.
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pubmed:publicationType |
Journal Article
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