| pubmed-article:9530168 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0033085 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:9530168 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:9530168 | pubmed:issue | 3 Pt 1 | lld:pubmed |
| pubmed-article:9530168 | pubmed:dateCreated | 1998-4-24 | lld:pubmed |
| pubmed-article:9530168 | pubmed:abstractText | L-Arginine supplementation has been shown to restore endothelium-derived nitric oxide production in several pathological states. The purpose of this study was to examine the effect of administration of exogenous L-arginine on the endotoxin-induced lung neutrophil accumulation and impairment of endothelium-dependent guanosine 3',5'-cyclic monophosphate (cGMP)-mediated pulmonary vasorelaxation in rats. Endothelium-dependent relaxation was tested by receptor-dependent [acetylcholine (ACh)] and receptor-independent (A-23187) pathways. Endothelium-independent relaxation was tested with sodium nitroprusside (SNP). In isolated pulmonary arterial rings, concentration-response curves were generated with ACh, A-23187, and SNP (10(-9) to 10(-6) M) 4 h after endotoxin (500 micrograms/kg i.p.) with and without prior administration of L-arginine (300 mg/kg i.p.). Lung neutrophil accumulation was determined by myeloperoxidase (MPO) assay. After endotoxin, lung neutrophil accumulation was significantly increased (MPO activity, 3.8 +/- 0.4 vs. 0.8 +/- 0.1 units/g lung weight in control cells; P < 0.05), which was prevented by L-arginine treatment (MPO activity, 1.3 +/- 0.3 units/g lung weight; P < 0.05 vs. endotoxin). Endotoxin produced a significant impairment of endothelium-dependent cGMP-mediated pulmonary vasorelaxation by receptor-dependent (ACh) and -independent (A-23187) pathways as well as of endothelium-independent relaxation (SNP). Prior treatment with L-arginine, but not with D-arginine, preserved endothelium-dependent vasorelaxation. Neither L- nor D-arginine influenced endotoxin-induced impairment of endothelium-independent, cGMP-mediated pulmonary vasorelaxation. We conclude that administration of exogenous L-arginine prevents endotoxin-induced lung neutrophil accumulation and attenuates its associated impairment of endothelium-dependent, cGMP-mediated pulmonary vasorelaxation. | lld:pubmed |
| pubmed-article:9530168 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9530168 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9530168 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9530168 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9530168 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9530168 | pubmed:author | pubmed-author:MeldrumD RDR | lld:pubmed |
| pubmed-article:9530168 | pubmed:author | pubmed-author:FullertonD... | lld:pubmed |
| pubmed-article:9530168 | pubmed:author | pubmed-author:McIntyreR... | lld:pubmed |
| pubmed-article:9530168 | pubmed:author | pubmed-author:SheridanB CBC | lld:pubmed |
| pubmed-article:9530168 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9530168 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:9530168 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9530168 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9530168 | pubmed:pagination | L337-42 | lld:pubmed |
| pubmed-article:9530168 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:meshHeading | pubmed-meshheading:9530168-... | lld:pubmed |
| pubmed-article:9530168 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9530168 | pubmed:articleTitle | L-arginine prevents lung neutrophil accumulation and preserves pulmonary endothelial function after endotoxin. | lld:pubmed |
| pubmed-article:9530168 | pubmed:affiliation | Department of Surgery, University of Colorado, Denver 80262, USA. | lld:pubmed |
| pubmed-article:9530168 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9530168 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9530168 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9530168 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9530168 | lld:pubmed |
