|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1998-2-13
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Nuclear receptors are a large family of ligand dependent transcription factors which participate in many diverse processes during development. In this report, we describe the cloning of the zebrafish thyroid hormone receptor alpha 1 (TR alpha 1) gene, the cellular counterpart of the viral oncogene v-erbA. TR alpha 1 is expressed during oogenesis and maternally supplied to the embryo. TR alpha 1 is expressed again after the mid blastula transition. By examining the effects of increased expression of TR alpha 1 on expression of a reporter gene which responds to both TR alpha 1 and retinoic acid receptors (RARs), we show that the zebrafish TR alpha 1 can act as a repressor during early zebrafish development before thyroid hormone is present in the embryo. In addition, our data suggest that TR alpha 1 can repress retinoic acid (RA)-signaling during early development. We propose that TR alpha 1 functions during early development as a transcriptional repressor, similar to the constitutive repressor activity of its viral counterpart v-erbA, which regulates anterior-posterior (A/P) patterning by repressing RA-signaling.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0301-4681
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
107-17
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9447705-Amino Acid Sequence,
pubmed-meshheading:9447705-Animals,
pubmed-meshheading:9447705-Base Sequence,
pubmed-meshheading:9447705-Blastocyst,
pubmed-meshheading:9447705-Blotting, Northern,
pubmed-meshheading:9447705-Cloning, Molecular,
pubmed-meshheading:9447705-Embryo, Nonmammalian,
pubmed-meshheading:9447705-Gastrula,
pubmed-meshheading:9447705-Gene Expression Regulation, Developmental,
pubmed-meshheading:9447705-Genes, Reporter,
pubmed-meshheading:9447705-Molecular Sequence Data,
pubmed-meshheading:9447705-Oogenesis,
pubmed-meshheading:9447705-RNA, Messenger,
pubmed-meshheading:9447705-Receptors, Retinoic Acid,
pubmed-meshheading:9447705-Receptors, Thyroid Hormone,
pubmed-meshheading:9447705-Repressor Proteins,
pubmed-meshheading:9447705-Ribonucleases,
pubmed-meshheading:9447705-Sequence Homology, Amino Acid,
pubmed-meshheading:9447705-Transcription, Genetic,
pubmed-meshheading:9447705-Tretinoin,
pubmed-meshheading:9447705-Zebrafish
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
The zebrafish thyroid hormone receptor alpha 1 is expressed during early embryogenesis and can function in transcriptional repression.
|
|
pubmed:affiliation |
Department of Genetics and Cell Biology, University of Minnesota, St. Paul 55108-1095, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
