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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1998-1-6
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pubmed:abstractText |
We have demonstrated previously that noncoding sequences of genes are a robust source of polymorphisms between mouse species when tested using single-strand conformation polymorphism (SSCP) analysis, and that these polymorphisms are useful for genetic mapping. In this report we demonstrate that presumptive 3'-untranslated region sequence obtained from expressed sequence tags (ESTs) can be analyzed in a similar fashion, and we have used this approach to map 262 loci using an interspecific backcross. These results demonstrate SSCP analysis of genes or ESTs is a simple and efficient means for the genetic localization of transcribed sequences, and is furthermore an approach that is applicable to any system for which there is sufficient sequence polymorphism.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-1345165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-1409609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-2030965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-2047873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-2687159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-7670480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-7670491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-7920646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8075499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8281011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8318734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8533086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8849440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8889549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-8889551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9371744-9166587
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1088-9051
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1085-93
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9371744-Animals,
pubmed-meshheading:9371744-Chromosome Mapping,
pubmed-meshheading:9371744-Crosses, Genetic,
pubmed-meshheading:9371744-DNA Mutational Analysis,
pubmed-meshheading:9371744-Gene Library,
pubmed-meshheading:9371744-Genetic Markers,
pubmed-meshheading:9371744-Mice,
pubmed-meshheading:9371744-Mice, Inbred AKR,
pubmed-meshheading:9371744-Mice, Inbred C3H,
pubmed-meshheading:9371744-Mice, Inbred C57BL,
pubmed-meshheading:9371744-Mice, Inbred DBA,
pubmed-meshheading:9371744-Mice, Inbred Strains,
pubmed-meshheading:9371744-Muridae,
pubmed-meshheading:9371744-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:9371744-Sequence Tagged Sites,
pubmed-meshheading:9371744-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
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pubmed:affiliation |
Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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