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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-2-12
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pubmed:abstractText |
The binding of the three dopamine transporter radioligands ([125I] beta-CIT, [125I] beta-CIT-FE, and [125I] beta-CIT-FP) was studied using whole-hemisphere autoradiography on postmortem human brains. The autoradiograms revealed an intense and homogeneous labeling of the nucleus caudatus and putamen but also to varying extent to serotonergic and noradrenergic transporters of neocortex and thalamus. The order of specificity estimated (striatum over neocortex ratios) was beta-CIT-FP > beta-CIT-FE > > beta-CIT, suggesting that beta-CIT-FE and beta-CIT-FP should be preferred for in vivo studies of the dopamine transporter in the human brain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-carbomethoxy-8-(3-fluoropropyl)-3-...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-fluoroethyl)-2-carbomethoxy-3-(...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nortropanes,
http://linkedlifedata.com/resource/pubmed/chemical/RTI 55,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Tropanes
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0969-8051
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9352533-Autoradiography,
pubmed-meshheading:9352533-Brain,
pubmed-meshheading:9352533-Brain Chemistry,
pubmed-meshheading:9352533-Carrier Proteins,
pubmed-meshheading:9352533-Cocaine,
pubmed-meshheading:9352533-Contrast Media,
pubmed-meshheading:9352533-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:9352533-Female,
pubmed-meshheading:9352533-Humans,
pubmed-meshheading:9352533-Iodine Radioisotopes,
pubmed-meshheading:9352533-Male,
pubmed-meshheading:9352533-Membrane Glycoproteins,
pubmed-meshheading:9352533-Membrane Transport Proteins,
pubmed-meshheading:9352533-Middle Aged,
pubmed-meshheading:9352533-Nerve Tissue Proteins,
pubmed-meshheading:9352533-Nortropanes,
pubmed-meshheading:9352533-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:9352533-Tomography, Emission-Computed,
pubmed-meshheading:9352533-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:9352533-Tropanes
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pubmed:year |
1997
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pubmed:articleTitle |
[125I] beta-CIT-FE and [125I] beta-CIT-FP are superior to [125I] beta-CIT for dopamine transporter visualization: autoradiographic evaluation in the human brain.
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pubmed:affiliation |
Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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