| pubmed-article:9261145 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9261145 | lifeskim:mentions | umls-concept:C0027834 | lld:lifeskim |
| pubmed-article:9261145 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9261145 | lifeskim:mentions | umls-concept:C0173931 | lld:lifeskim |
| pubmed-article:9261145 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9261145 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:9261145 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:9261145 | pubmed:dateCreated | 1997-9-15 | lld:pubmed |
| pubmed-article:9261145 | pubmed:abstractText | The POU domain transcription factor Brn-3a is able to stimulate neurite outgrowth when overexpressed in the neuronal ND7 cell line, whereas the closely related Brn-3b factor does not have this effect. We show that Brn-3a overexpression also enhances the expression of the three neurofilament genes at both the mRNA and protein levels, whereas Brn-3b overexpression has no effect. In addition Brn-3a activates the three neurofilament gene promoters in co-transfection assays in both neuronal and non-neuronal cells. As observed for enhanced neurite outgrowth, the stimulation of neurofilament gene expression and activation of the neurofilament gene promoters is observed with the isolated POU domain of Brn-3a. A single amino acid change in the POU homeodomain of Brn-3a to the equivalent amino acid in Brn-3b abolishes its ability to activate the neurofilament promoters, whereas the reciprocal change converts Brn-3b to an activator of these promoters. | lld:pubmed |
| pubmed-article:9261145 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9261145 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9261145 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9261145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9261145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9261145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9261145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9261145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9261145 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9261145 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9261145 | pubmed:author | pubmed-author:MorrinP APA | lld:pubmed |
| pubmed-article:9261145 | pubmed:author | pubmed-author:SchlaepferW... | lld:pubmed |
| pubmed-article:9261145 | pubmed:author | pubmed-author:SmithM DMD | lld:pubmed |
| pubmed-article:9261145 | pubmed:author | pubmed-author:SchwartzM LML | lld:pubmed |
| pubmed-article:9261145 | pubmed:author | pubmed-author:LatchmanD SDS | lld:pubmed |
| pubmed-article:9261145 | pubmed:author | pubmed-author:DawsonS JSJ | lld:pubmed |
| pubmed-article:9261145 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9261145 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:9261145 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:9261145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9261145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9261145 | pubmed:pagination | 21325-33 | lld:pubmed |
| pubmed-article:9261145 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9261145 | pubmed:meshHeading | pubmed-meshheading:9261145-... | lld:pubmed |
| pubmed-article:9261145 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9261145 | pubmed:articleTitle | Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor. | lld:pubmed |
| pubmed-article:9261145 | pubmed:affiliation | Department of Molecular Pathology, University College London Medical School, London W1P 6DB, United Kingdom. | lld:pubmed |
| pubmed-article:9261145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9261145 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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