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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-4-9
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pubmed:abstractText |
This study sought to 1) test the hypothesis that in the setting of bradycardia and drug-induced action potential prolongation, multiple foci of early afterdepolarizations (EADs) result in beat to beat changes in the origin and direction of the excitation wave front and are responsible for polymorphic arrhythmias; and 2) determine whether EADs may initiate nonstationary reentry, giving rise to the typical torsade de pointes (TDP) pattern.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0735-1097
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
831-42
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9091531-Action Potentials,
pubmed-meshheading:9091531-Animals,
pubmed-meshheading:9091531-Anti-Arrhythmia Agents,
pubmed-meshheading:9091531-Arrhythmias, Cardiac,
pubmed-meshheading:9091531-Electrocardiography,
pubmed-meshheading:9091531-Heart,
pubmed-meshheading:9091531-Heart Conduction System,
pubmed-meshheading:9091531-Image Processing, Computer-Assisted,
pubmed-meshheading:9091531-Models, Cardiovascular,
pubmed-meshheading:9091531-Organ Culture Techniques,
pubmed-meshheading:9091531-Perfusion,
pubmed-meshheading:9091531-Piperidines,
pubmed-meshheading:9091531-Pyridines,
pubmed-meshheading:9091531-Quinidine,
pubmed-meshheading:9091531-Rabbits,
pubmed-meshheading:9091531-Torsades de Pointes
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pubmed:year |
1997
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pubmed:articleTitle |
Optical mapping of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart.
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pubmed:affiliation |
Department of Pharmacology, State University of New York Health Science Center, Syracuse 13210, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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