Linked Life Data

8797195

Source:http://linkedlifedata.com/resource/pubmed/id/8797195

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-2
pubmed:abstractText
Dopamine (DA) receptor activation has been shown to affect the striatal complex in a multidimensional manner. However, the question of whether its net effect on postsynaptic targets in the nucleus accumbens and striatum is excitatory or inhibitory in nature has been a topic of controversy for some time. This study focuses on the effects of DA agonists on indices of postsynaptic cell membrane excitability in nucleus accumbens neurons, such as the amount of intracellular current injection required to elicit spike firing and the membrane potential at which action potentials are evoked. Administration of the nonspecific D1/D2 DA agonist apomorphine induced a membrane depolarization that was not mimicked by the D1 agonist SKF 38393, by the D2 agonist quinpirole, or by the combined administration of both drugs. On the other hand, subsets of neurons responded to apomorphine or combined D1/D2 agonist administration with a response that reversed near -90 mV. Following the administration of apomorphine or the combined administration of the D1 and D2 agonists, nucleus accumbens neurons required significantly higher amplitudes of depolarizing current injection to elicit spike firing. These results suggest that coactivation of D1 and D2 receptors on accumbens neurons causes a reduction in their membrane excitability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-97
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Dopaminergic reduction of excitability in nucleus accumbens neurons recorded in vitro.
pubmed:affiliation
Department of Neuroscience, University of Pittsburgh, PA 15260, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't