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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1996-6-19
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pubmed:abstractText |
Alveolar type II cells are not present in normal epithelium of canine segmental bronchi but after carcinogen exposure they do occur in intra-epithelial lesions with all degrees of atypia and in invasive lesions with different glandular growth patterns. Immunohistochemistry for proliferation markers (PCNA; Ki-67) strongly suggest that such novel type II cells are pluripotential stem cells in canine bronchial carcinogenesis. Very likely, bronchial carcinogenesis is subject to an oncofetal mechanism of differentiation: bronchial epithelial retrodifferentiation followed by novel differentiation of alveolar tumor stem cells.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3835
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8620472-Animals,
pubmed-meshheading:8620472-Antigens, Neoplasm,
pubmed-meshheading:8620472-Bronchial Neoplasms,
pubmed-meshheading:8620472-Dogs,
pubmed-meshheading:8620472-Epithelium,
pubmed-meshheading:8620472-Ki-67 Antigen,
pubmed-meshheading:8620472-Methylcholanthrene,
pubmed-meshheading:8620472-Mice,
pubmed-meshheading:8620472-Mice, Nude,
pubmed-meshheading:8620472-Neoplasm Proteins,
pubmed-meshheading:8620472-Neoplastic Stem Cells,
pubmed-meshheading:8620472-Nuclear Proteins,
pubmed-meshheading:8620472-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:8620472-Proteolipids,
pubmed-meshheading:8620472-Pulmonary Alveoli,
pubmed-meshheading:8620472-Pulmonary Surfactant-Associated Proteins,
pubmed-meshheading:8620472-Pulmonary Surfactants
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pubmed:year |
1996
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pubmed:articleTitle |
Alveolar stem cells in canine bronchial carcinogenesis.
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pubmed:affiliation |
Department of Pneumology, Leiden University, The Netherlands. have@rullf2.leidenuniv.nl
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pubmed:publicationType |
Journal Article
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