| pubmed-article:8605097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C0555198 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C0053932 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8605097 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8605097 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8605097 | pubmed:dateCreated | 1996-5-17 | lld:pubmed |
| pubmed-article:8605097 | pubmed:abstractText | The distribution of bone morphogenetic protein (BMP) type I receptors and the activin type I receptor (ActR-I) was investigated in 16 cases of human glioma and five cases of non-tumourous gliosis tissue by immunohistochemical technique. Both BMP type IA (BMPR-IA) and the type IB (BMPR-IB) receptors were detected in human glioma cells. A significant increase in BMPR-IB in tumour cells was observed in malignant glioma compared with both low-grade astrocytomas (n=16, P<0.005) and gliosis (n=13, P<0.001). However, enhancement of BMPR-IA staining was moderate and ActR-I staining was only weakly expressed in the malignant glioma tumours. Osteogenic protein (OP)-1/BMP-7, which is known to bind BMPR-IA, BMPR-IB and ActR-I, was expressed in nervous tissue and was also detected in anaplastic areas of malignant glioma. In contrast to the tissue materials, BMPR-IA was expressed to a stronger degree than BMPR-IB in human glioma cell lines; the growth of these cells was suppressed by OP-1. These results suggest the presence of BMP receptors and a functional role for BMPs in malignant glioma. | lld:pubmed |
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| pubmed-article:8605097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8605097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8605097 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8605097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8605097 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8605097 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:KatoMM | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:YamashitaHH | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:YamadaNN | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:HeldinC HCH | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:DoraG LGL | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:SampathT KTK | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:MiyazonoKK | lld:pubmed |
| pubmed-article:8605097 | pubmed:author | pubmed-author:ten DijkePP | lld:pubmed |
| pubmed-article:8605097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8605097 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:8605097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8605097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8605097 | pubmed:pagination | 624-9 | lld:pubmed |
| pubmed-article:8605097 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8605097 | pubmed:year | 1996 | lld:pubmed |
