Linked Life Data

8592226

Source:http://linkedlifedata.com/resource/pubmed/id/8592226

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pubmed-article:8592226pubmed:abstractTextSpinal nerve root avulsions frequently occur in brachial plexus injuries caused by traction. Such lesions are considered to afflict the central nervous system (CNS) and are, therefore, believed to be beyond surgical repair. The present experimental study was initiated to challenge this hypothesis. The ventral rootlets of C-7 were avulsed from the spinal cord in 28 cats via an anterior approach and subsequently reimplanted into the cord at the site of origin. In nonoperated control cats and cats undergoing reimplantation, electrophysiological experiments were performed and horseradish peroxidase was administered to the spinal nerve on the reimplanted side after survival times ranging from 6 to 293 days. Spinal cord sections in all cats were stained for neurofilament, acetylcholinesterase (AChE), Nissl, and glial fibrillary acidic protein. Horseradish peroxidase-labeled ventral horn motoneurons were found as early as 14 days after reimplantation and their number increased with time. On Days 209 and 293, the number of labeled neurons equaled the number of labeled ventral horn neurons in the two control cats that did not undergo surgery. Starting on Day 6 after reimplantation, the appearance of the ventral horn and the white matter in the neurofilament, AChE, and Nissl-stained sections changed as a result of the CNS response to the injury. A return to their normal appearance could be observed in these stainings from Day 209 onward. Glial fibrillary acidic protein-positive astrocytic tissue was consistently found in the ventral horn and in the white matter reimplantation area. From Day 69 onward, electrophysiological stimulation of the spinal nerve C-7 on the reimplanted side elicited an electromyogram response in the spinodeltoid muscle. The latency and threshold intensity of the C-7 responses were initially increased but equalized to match the nonoperated controls between 98 and 122 days after reimplantation. The results of this study show that functional regeneration of ventral horn neurons after root avulsion and subsequent reimplantation in the cat is possible.lld:pubmed
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pubmed-article:8592226pubmed:pagination234-43lld:pubmed
pubmed-article:8592226pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:8592226pubmed:year1996lld:pubmed
pubmed-article:8592226pubmed:articleTitleReinnervation of avulsed and reimplanted ventral rootlets in the cervical spinal cord of the cat.lld:pubmed
pubmed-article:8592226pubmed:affiliationDepartment of Neurosurgery, University of Leiden, The Netherlands.lld:pubmed
pubmed-article:8592226pubmed:publicationTypeJournal Articlelld:pubmed
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