Linked Life Data

8554561

Source:http://linkedlifedata.com/resource/pubmed/id/8554561

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-2-22
pubmed:abstractText
To examine thyroid hormone regulation of the pituitary receptor for hypothalamic growth hormone (GH)-releasing factor (GRF), we studied effects of hypothyroidism on the pituitary GRF receptor (GRF-R) mRNA and its related parameters in rats. Thyroidectomy (Tx) induced a 61-65% reduction in GRF-R mRNA levels, which was significantly reversed with thyroxine (T4) replacement for 5 days at a dose of 1 microgram/100 g/day. Pituitary GH contents changed parallel to GRF-R mRNA levels following the Tx and T4 replacement. In contrast, Tx enhanced GRF release > 2 fold, which was not reversed with the regime of T4 replacement. These results indicate that thyroid hormone promotes pituitary GRF-R gene expression, not by modulating GRF secretion, but by acting on the pituitary directly. The decline in GRF receptor expression would contribute to somatotroph failure by rendering the pituitary refractory to the increased GRF signal in hypothyroidism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1087-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Thyroid hormone regulation of gene expression of the pituitary growth hormone-releasing factor receptor.
pubmed:affiliation
Department of Medicine, Tokyo Women's Medical College, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't