Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
1977-5-12
|
| pubmed:abstractText |
To evaluate hyaluronidase's effect in reducing post-infarction myocardial necrosis, we randomized 91 patients with anterior infarction to control (45) or to hyaluronidase-treatment (46) groups. A 35-lead precordial electrocardiogram was recorded on admission and seven days later. Hyaluronidase was administered intravenously after the first electrocardiogram and every six hours for 48 hours. QRS-complex changes were analyzed to assess the drug's effect. Precordial sites with ST-segment elevation (larger than or equal to 0.15 mV) on the initial electrocardiogram that retained an R wave were considered vulnerable for the development of electrocardiographic signs of necrosis. The sum of R-wave voltages of vulnerable sites fell more in the control group than in the hyaluronidase group (70.9 +/- 3.6 per cent [+/- 1 S.E.M.] vs 54.2 +/- 5.0 per cent P less than 0.01). Q waves appeared in 59.3 +/- 4.9 per cent of the vulnerable sites in control versus 46.4 +/- 4.9 per cent in hyaluronidase-treated patients (P less than 0.05). Thus, hyaluronidase reduced the frequency of electrocardiographic signs of myocardial necrosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0028-4793
|
| pubmed:author |
pubmed-author:AskenaziJJ,
pubmed-author:BobbaPP,
pubmed-author:BraunwaldEE,
pubmed-author:CarpentierJJ,
pubmed-author:ChazovE IEI,
pubmed-author:ChiarielloMM,
pubmed-author:DistanteAA,
pubmed-author:HeyndrickxG RGR,
pubmed-author:HillisL DLD,
pubmed-author:LibbyPP,
pubmed-author:MarokoP RPR,
pubmed-author:MullenJ AJA,
pubmed-author:RaabeD SDS,
pubmed-author:RadvanyPP,
pubmed-author:RayMM,
pubmed-author:ReshetnayaN INI,
pubmed-author:SalernoJJ,
pubmed-author:TavazziLL
|
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
296
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
898-903
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:846510-Acute Disease,
pubmed-meshheading:846510-Adult,
pubmed-meshheading:846510-Aged,
pubmed-meshheading:846510-Electrocardiography,
pubmed-meshheading:846510-Female,
pubmed-meshheading:846510-Humans,
pubmed-meshheading:846510-Hyaluronoglucosaminidase,
pubmed-meshheading:846510-Injections, Intradermal,
pubmed-meshheading:846510-Male,
pubmed-meshheading:846510-Middle Aged,
pubmed-meshheading:846510-Myocardial Infarction,
pubmed-meshheading:846510-Necrosis
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Favorable effects of hyaluronidase on electrocardiographic evidence of necrosis in patients with acute myocardial infarction.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|