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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1993-9-21
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pubmed:abstractText |
The bilateral efferent supply to the inner ear receptor fields is located in the hindbrain. In ovo injections of Dil into the common facial/vestibulo-acoustic nerve root at 3 days of chick development (stage 16) followed by analysis at 7 days has revealed the origin of the contralateral efferent neurons of the inner ear and their relation to the transient hindbrain rhombomeres. These neurons have a rhombomere 4-specific origin and form their commissure not by axonal outgrowth but, unusually, by transmedian cell migration into the contralateral rhombomere 4 and rhombomere 5. Neurons first project their axons from the ipsilateral basal plate through the VII/VIIIth nerve exit point and then migrate in the opposite direction, crossing the floor plate at stage 19-21. This rhombomere-specific cell behavior provides evidence at the cellular level that segmentation is intimately involved in establishing the pattern of this region of the CNS.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0896-6273
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-20
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8394719-Animals,
pubmed-meshheading:8394719-Auditory Pathways,
pubmed-meshheading:8394719-Carbocyanines,
pubmed-meshheading:8394719-Cell Line,
pubmed-meshheading:8394719-Cell Movement,
pubmed-meshheading:8394719-Chick Embryo,
pubmed-meshheading:8394719-Efferent Pathways,
pubmed-meshheading:8394719-Embryonic and Fetal Development,
pubmed-meshheading:8394719-Facial Nerve,
pubmed-meshheading:8394719-Fluorescent Dyes,
pubmed-meshheading:8394719-Neurons, Efferent,
pubmed-meshheading:8394719-Synaptic Transmission,
pubmed-meshheading:8394719-Vestibule, Labyrinth,
pubmed-meshheading:8394719-Vestibulocochlear Nerve
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pubmed:year |
1993
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pubmed:articleTitle |
Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline.
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pubmed:affiliation |
Division of Anatomy and Cell Biology, United Medical School, Guy's Hospital, London, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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