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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1994-7-28
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pubmed:abstractText |
We have studied the ability of c-myc and bcl-2 oncogenes to modulate p53 function. Our studies show that coincident expression of human Bcl-2 protein with p53 prolongs survival of murine erythroleukemia cells. This effect was associated with a loss of the G1 specificity of p53-mediated cell cycle arrest. Furthermore, we found that the c-myc and bcl-2 genes cooperate to inhibit p53 functions. Coexpression of bcl-2 and c-myc can totally overcome p53-induced apoptosis and cell cycle arrest by altering the subcellular trafficking of p53 during the cell cycle: the p53 remains in the cytoplasm of the cotransfected cells during a critical period in G1. This finding suggests a mechanism by which normal hematopoietic progenitors can survive and proliferate despite p53 expression and by which the inappropriate expression of bcl-2 and c-myc can cooperate in transformation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1323840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1353891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1406975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1436095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1623518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1688645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1694008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1835668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1852210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1868448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-1871110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-2046748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-2143698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-2184193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-2663470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-3262202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-3285208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-3302722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-3528863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-3874430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-7688182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-8353276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-8360476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-8400252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-8402648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-8417361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016082-8479522
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
91
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pubmed:geneSymbol |
Ha-ras,
bcl-2,
c-myc,
p53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5878-82
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8016082-Animals,
pubmed-meshheading:8016082-Antibodies, Monoclonal,
pubmed-meshheading:8016082-Cell Cycle,
pubmed-meshheading:8016082-Cell Line,
pubmed-meshheading:8016082-Cell Survival,
pubmed-meshheading:8016082-Flow Cytometry,
pubmed-meshheading:8016082-Genes, myc,
pubmed-meshheading:8016082-Genes, p53,
pubmed-meshheading:8016082-Humans,
pubmed-meshheading:8016082-Mice,
pubmed-meshheading:8016082-Protein-Tyrosine Kinases,
pubmed-meshheading:8016082-Proto-Oncogene Proteins,
pubmed-meshheading:8016082-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8016082-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:8016082-Proto-Oncogenes,
pubmed-meshheading:8016082-RNA, Messenger,
pubmed-meshheading:8016082-Transfection,
pubmed-meshheading:8016082-Tumor Cells, Cultured,
pubmed-meshheading:8016082-Tumor Suppressor Protein p53
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pubmed:year |
1994
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pubmed:articleTitle |
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.
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pubmed:affiliation |
Department of Medicine, University of Michigan Medical Center, Ann Arbor 48109.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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