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rdf:type |
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lifeskim:mentions |
umls-concept:C0016365,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036751,
umls-concept:C0038866,
umls-concept:C0087111,
umls-concept:C0205095,
umls-concept:C0205227,
umls-concept:C0439228,
umls-concept:C0439596,
umls-concept:C0456962,
umls-concept:C0504074,
umls-concept:C0683134,
umls-concept:C1280500,
umls-concept:C1533691,
umls-concept:C1548574,
umls-concept:C1948023,
umls-concept:C2603343
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pubmed:issue |
1-2
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pubmed:dateCreated |
1994-7-21
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pubmed:abstractText |
Changes in the extracellular concentration of 5-HT evoked by electrical stimulation of brain slices containing either dorsal raphe nucleus (DRN) or suprachiasmatic nucleus (SCN) from rats treated for 21 days with fluoxetine (5 mg/kg; i.p.) or water were monitored using fast cyclic voltammetry (FCV). Stimulated 5-HT overflow was enhanced significantly in both brain regions after 21 days treatment with fluoxetine but there was no change in the half time for re-uptake (t1/2). Concentration response curves for inhibition of electrically stimulated 5-HT overflow by 8-OH-DPAT (5-HT1a receptor agonist) or RU24969 (5-HT1b receptor agonist) in the DRN or SCN respectively were obtained in slices prepared from both groups of animals. There was a significant shift to the right in the dose-response curve for RU24969 in the SCN in fluoxetine treated animals but a shift to the left for the dose-response curve for 8-OH-DPAT in the DRN. These data suggest that down regulation of the 5-HT1b autoreceptors occurs in an axon terminal region (SCN) but that there is a sensitisation of 5-HT1a autoreceptor mechanisms controlling 5-HT overflow in the DRN.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
640
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
328-35
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8004461-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:8004461-Animals,
pubmed-meshheading:8004461-Behavior, Animal,
pubmed-meshheading:8004461-Body Weight,
pubmed-meshheading:8004461-Electric Stimulation,
pubmed-meshheading:8004461-Electrophysiology,
pubmed-meshheading:8004461-Fluoxetine,
pubmed-meshheading:8004461-Indoles,
pubmed-meshheading:8004461-Male,
pubmed-meshheading:8004461-Methiothepin,
pubmed-meshheading:8004461-Presynaptic Terminals,
pubmed-meshheading:8004461-Raphe Nuclei,
pubmed-meshheading:8004461-Rats,
pubmed-meshheading:8004461-Rats, Wistar,
pubmed-meshheading:8004461-Serotonin,
pubmed-meshheading:8004461-Serotonin Receptor Agonists,
pubmed-meshheading:8004461-Suprachiasmatic Nucleus
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pubmed:year |
1994
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pubmed:articleTitle |
Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro.
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pubmed:affiliation |
Department of Pharmacology, Queen Mary and Westfield College, London, UK.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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