Linked Life Data

7898081

Source:http://linkedlifedata.com/resource/pubmed/id/7898081

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-4-24
pubmed:abstractText
The effects of acute intravenous (i.v.) versus long-term oral (p.o.) verapamil administration on diastolic function were studied in 20 patients with hypertrophic cardiomyopathy (HCM). We used a tip manometer catheter to record left ventricular pressure (LVP) tracings and a nuclear probe to measure LV volume changes. Infusion of verapamil resulted in an increase in time constant of relaxation (+15%, p < 0.001); LV peak filling rate, heart rate (HR), and stiffness constant of the diastolic pressure-volume relation were unchanged. During 18-week p.o. verapamil treatment, HR decreased (-16%, p < 0.0005) and the atrial contribution to LV filling decreased (-27%, p < 0.05); other parameters differed significantly from baseline values. Results demonstrate that acute i.v. versus long-term p.o. verapamil administration have different effects on diastolic function in HCM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
969-73
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Acute intravenous versus chronic oral drug effects of verapamil on left ventricular diastolic function in patients with hypertrophic cardiomyopathy.
pubmed:affiliation
Department of Cardiology, University Hospital Groningen, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial