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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1995-4-6
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pubmed:abstractText |
The response to an inactivated hepatitis A vaccine was assessed in 307 persons: 163 Alaska Native children, ages 3-6 years, and 144 Native (84) and non-Native (60) adults. All adults received the same vaccine schedule (0, 1, and 12 months), whereas children were randomized to receive three different schedules (0, 1, and 6; 0, 1, and 2; or 0, 1, and 12 months). After one dose, 141 (96%) of 147 children and 129 (90%) of 143 adults responded with levels of antibody to hepatitis A virus > 20 mIU/mL. After three doses, all participants responded. The geometric mean titer (GMT) 1 month after the third dose was significantly higher in children who received the third dose 12 months after the first dose rather than 2 months after the first dose. While there were differences in the GMT of some blood samples by age, sex, and ethnicity, all participants responded to the vaccine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis A Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis A Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Inactivated,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Hepatitis Vaccines
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
676-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7876615-Adolescent,
pubmed-meshheading:7876615-Adult,
pubmed-meshheading:7876615-Age Factors,
pubmed-meshheading:7876615-Alaska,
pubmed-meshheading:7876615-Child, Preschool,
pubmed-meshheading:7876615-Hepatitis A Antibodies,
pubmed-meshheading:7876615-Hepatitis A Vaccines,
pubmed-meshheading:7876615-Hepatitis Antibodies,
pubmed-meshheading:7876615-Hepatovirus,
pubmed-meshheading:7876615-Humans,
pubmed-meshheading:7876615-Indians, North American,
pubmed-meshheading:7876615-Sex Factors,
pubmed-meshheading:7876615-Vaccines, Inactivated,
pubmed-meshheading:7876615-Viral Hepatitis Vaccines
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pubmed:year |
1995
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pubmed:articleTitle |
Immunogenicity of an inactivated hepatitis A vaccine in Alaska Native children and Native and non-Native adults.
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pubmed:affiliation |
Alaska Native Medical Center, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage 99501.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|