Linked Life Data

7771585

Source:http://linkedlifedata.com/resource/pubmed/id/7771585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 2
pubmed:dateCreated
1995-7-6
pubmed:abstractText
The aims of the present study were to determine basic kinetic parameters and the nycthemeral production rate of melatonin in the horse. Seven pony mares were used for the kinetic studies. Five other pony mares were used under long and short days for the production rate studies. Melatonin was administered by intravenous, oral, and intragastric routes at different dose levels. The plasma melatonin clearance was 1.02 +/- 0.31 l.kg-1.h-1, and the volume of distribution was 0.89 +/- 0.53 l/kg for the 0.4 microgram/kg melatonin dose. The systemic availability after oral and intragastric administration was consistently low (< or = 10%). The hourly melatonin production rates during short (36 +/- 33.6 ng.kg-1.h-1) and long nights (42 +/- 24.0 ng.kg-1.h-1) were not significantly different. It is concluded that the oral dose of exogenous melatonin required to control reproductive pattern in horses would need to be 10 times higher than the nocturnal melatonin production (0.5 microgram/kg) to obtain a physiological plasma melatonin concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
268
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1236-41
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Kinetic studies and production rate of melatonin in pony mares.
pubmed:affiliation
Institut National de la Recherche Agronomique de Tours, Physiologie de la Reproduction des Mammifères Domestiques, Nouzilly, France.
pubmed:publicationType
Journal Article