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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1995-5-30
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pubmed:abstractText |
The effect of consumption of Brussels sprouts on levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in human urine was investigated in 10 healthy, male, non-smoking volunteers. Following a 3 week run-in period, five volunteers continued on a diet free of cruciferous vegetables for a subsequent 3 week intervention period (control group), while the other five (sprouts group) consumed 300 g of cooked Brussels sprouts per day, at the expense of 300 g of a glucosinolate-free vegetable. Levels of 8-oxodG in 24 h urine samples were measured by HPLC. In the control group there was no difference between the two periods in levels of 8-oxodG (P = 0.72). In contrast, in the sprouts group the levels of 8-oxodG were decreased by 28% during the intervention period (P = 0.039). The present findings support the results of epidemiologic studies that consumption of cruciferous vegetables may result in a decreased cancer risk.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-oxo-7-hydrodeoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Anticarcinogenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antimutagenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0143-3334
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
969-70
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7728983-Anticarcinogenic Agents,
pubmed-meshheading:7728983-Antimutagenic Agents,
pubmed-meshheading:7728983-Antioxidants,
pubmed-meshheading:7728983-Brassica,
pubmed-meshheading:7728983-DNA,
pubmed-meshheading:7728983-DNA Damage,
pubmed-meshheading:7728983-Deoxyguanosine,
pubmed-meshheading:7728983-Diet,
pubmed-meshheading:7728983-Humans,
pubmed-meshheading:7728983-Male,
pubmed-meshheading:7728983-Oxidation-Reduction,
pubmed-meshheading:7728983-Vegetables
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pubmed:year |
1995
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pubmed:articleTitle |
Reduction of oxidative DNA-damage in humans by brussels sprouts.
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pubmed:affiliation |
TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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