Linked Life Data

76936

Source:http://linkedlifedata.com/resource/pubmed/id/76936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8072
pubmed:dateCreated
1978-6-28
pubmed:abstractText
Chronic hepatic necrosis developed in a man who had been taking 4 g of paracetamol daily for about a year (cumulative dose 1700 g). Liver biopsy done 23 days after the drug was stopped showed prominent diffuse central necrosis and portal changes. Repeat biopsy 5 months later showed chronic active hepatitis. This prompted anti-inflammatory treatment, with subsequent improvement in liver histology. Liver concentrations of reduced glutathione and paracetamol metabolism, assessed 1-1 1/2 years after drug was stopped, were normal; the basis for this patient's drug sensitivity is thus unclear. In some patients, chronic ingestion of therapeutic doses of paracetamol may produce hepatic necrosis and hepatitis which persist long after the drug has been discontinued.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1016-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Chronic hepatic inflammation and fibrosis due to low doses of paracetamol.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Case Reports