| pubmed-article:7653183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0033860 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0206527 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0332461 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0059386 | lld:lifeskim |
| pubmed-article:7653183 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:7653183 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7653183 | pubmed:dateCreated | 1995-9-28 | lld:pubmed |
| pubmed-article:7653183 | pubmed:abstractText | Recent studies have demonstrated the important role of CD4+ T cells in the pathophysiology of psoriasis. One of the current hypotheses is that triggering of the psoriatic inflammatory process could be secondary to CD4+ T cell activation by bacterial superantigens in the skin. In this study, IL-2-derived T cell lines were recovered from the blood and the skin of 4 patients with chronic plaque type psoriasis and of 2 patients with allergic contact dermatitis (ACD). Blood and skin T cell lines were tested for their ability to proliferate in vitro to staphylococcal enterotoxin B (SEB) presented by MHC class II expressing antigen-presenting cells. The results showed a significantly higher SEB-induced T cell proliferation in skin T cell lines as compared to blood T cell lines in 3 out of 4 psoriatic patients and in one of the 2 ACD patients. No difference between the skin and blood T cells for their response to phytohemagglutinin was observed. Furthermore the blood T cell lines from both patients and control individuals responded equally well to SEB. Thus psoriatic skin T cell lines were characterized by an enrichment in SEB-responding T cells. Since similar enhancement of SEB-responsive T cells was occasionally found in ACD patients, we propose that SEB could be an environmental factor associated with rather than responsible for psoriatic inflammation. | lld:pubmed |
| pubmed-article:7653183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7653183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653183 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7653183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7653183 | pubmed:month | May | lld:pubmed |
| pubmed-article:7653183 | pubmed:issn | 0001-5555 | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:NicolasJ FJF | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:SchmittDD | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:BourHH | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:ClaudyAA | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:KrastevaMM | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:DemidemAA | lld:pubmed |
| pubmed-article:7653183 | pubmed:author | pubmed-author:GarrigueJ LJL | lld:pubmed |
| pubmed-article:7653183 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7653183 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:7653183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7653183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7653183 | pubmed:pagination | 218-21 | lld:pubmed |
| pubmed-article:7653183 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
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| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
| pubmed-article:7653183 | pubmed:meshHeading | pubmed-meshheading:7653183-... | lld:pubmed |
| pubmed-article:7653183 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7653183 | pubmed:articleTitle | In vitro T cell response to staphylococcal enterotoxin B superantigen in chronic plaque type psoriasis. | lld:pubmed |
| pubmed-article:7653183 | pubmed:affiliation | Dermographical Clinic, Edouard Herriot Hospital, Lyon, France. | lld:pubmed |
| pubmed-article:7653183 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7653183 | lld:pubmed |
