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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-8-11
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pubmed:abstractText |
The role of humoral immunity in the protection of vaccinated SJL/J mice from central nervous system disease induced by the DA strain (DAV) of Theiler's murine encephalomyelitis virus was investigated in B-cell-deficient mice. Mice were depleted of B cells by treatment with a mouse monoclonal antibody specific for immunoglobulin M. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease. CD4+ T cells are required in this model of protection to provide help for the development of an antiviral antibody response in the central nervous system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-1586954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-164412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-1645797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-1650475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-1705992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-185333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-2038955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-2333032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-2416835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-2539504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-2653373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-310853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-3134601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-3159817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-3258641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-3339243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-381165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-5439579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6087205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6173237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6230400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6411818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6690619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6970212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-6977567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-7783595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-8317548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7609086-8331166
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5152-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
1995
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pubmed:articleTitle |
B-lymphocyte requirement for vaccine-mediated protection from Theiler's murine encephalomyelitis virus-induced central nervous system disease.
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pubmed:affiliation |
Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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