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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-12-26
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pubmed:abstractText |
We investigated the synergistic effect of anti-HLA class II monoclonal antibodies on proliferative responses to ovalbumin (OA) of T cell line (TCL) cells from five hen's-egg-sensitive patients. Among the five patients, the proliferation of the TCL cells from two patients with AD who have a low immune reaction was restored by the anti-HLA-DQ monoclonal antibodies, and the proliferation of the TCL cells from the other three patients was inhibited by the anti-HLA-DP monoclonal antibodies. These results suggest that a component of the T cell repertoire reactive with OA in hen's-egg-sensitive patients may be restricted by HLA-DP molecules. Furthermore, in hen's-egg-sensitive patients with AD who have a low immune reaction, low responsiveness may be regulated by HLA-DQ molecules.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0254-9670
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-10
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7576714-Animals,
pubmed-meshheading:7576714-Antibodies, Monoclonal,
pubmed-meshheading:7576714-Cell Line,
pubmed-meshheading:7576714-Chickens,
pubmed-meshheading:7576714-Child,
pubmed-meshheading:7576714-Child, Preschool,
pubmed-meshheading:7576714-Dermatitis, Atopic,
pubmed-meshheading:7576714-Dose-Response Relationship, Immunologic,
pubmed-meshheading:7576714-Egg White,
pubmed-meshheading:7576714-Epitopes,
pubmed-meshheading:7576714-Female,
pubmed-meshheading:7576714-HLA-D Antigens,
pubmed-meshheading:7576714-Humans,
pubmed-meshheading:7576714-Hypersensitivity, Immediate,
pubmed-meshheading:7576714-Immunoglobulin E,
pubmed-meshheading:7576714-Infant,
pubmed-meshheading:7576714-Lymphocyte Activation,
pubmed-meshheading:7576714-Male,
pubmed-meshheading:7576714-Ovalbumin,
pubmed-meshheading:7576714-Radioallergosorbent Test,
pubmed-meshheading:7576714-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
T cell proliferation restricted by HLA class II molecules in patients with hen's egg allergy.
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pubmed:affiliation |
Department of Pediatrics, Gifu University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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