|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
25
|
|
pubmed:dateCreated |
1995-7-31
|
|
pubmed:abstractText |
YY1 is a zinc finger transcription factor with unusual structural and functional features. In a yeast two-hybrid screen, two cellular proteins, cyclophilin A (CyPA) and FK506-binding protein 12 (FKBP12), interacted with YY1. These interactions are specific and also occur in mammalian cells. Cyclosporin A and FK506 efficiently disrupt the YY1-CyPA and YY1-FKBP12 interactions. Overexpression of human CyPA and FKBP12 have different effects on YY1-regulated transcription with these effects being promoter-dependent. These results suggest that immunophilins may be mediators in the functional role of YY1.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Isomerases,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chloramphenicol O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endodeoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Erythroid-Specific DNA-Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidylprolyl Isomerase,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/YY1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/YY1 protein, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
270
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
15187-93
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:7541038-Amino Acid Isomerases,
pubmed-meshheading:7541038-Carrier Proteins,
pubmed-meshheading:7541038-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:7541038-Cyclosporine,
pubmed-meshheading:7541038-DNA-Binding Proteins,
pubmed-meshheading:7541038-Endodeoxyribonucleases,
pubmed-meshheading:7541038-Erythroid-Specific DNA-Binding Factors,
pubmed-meshheading:7541038-HeLa Cells,
pubmed-meshheading:7541038-Heat-Shock Proteins,
pubmed-meshheading:7541038-Humans,
pubmed-meshheading:7541038-Peptidylprolyl Isomerase,
pubmed-meshheading:7541038-Promoter Regions, Genetic,
pubmed-meshheading:7541038-Recombinant Fusion Proteins,
pubmed-meshheading:7541038-TATA Box,
pubmed-meshheading:7541038-Tacrolimus,
pubmed-meshheading:7541038-Tacrolimus Binding Proteins,
pubmed-meshheading:7541038-Transcription, Genetic,
pubmed-meshheading:7541038-Transcription Factors,
pubmed-meshheading:7541038-Transfection,
pubmed-meshheading:7541038-YY1 Transcription Factor,
pubmed-meshheading:7541038-Zinc Fingers
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity.
|
|
pubmed:affiliation |
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78245-3207, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
