Linked Life Data

7528237

Source:http://linkedlifedata.com/resource/pubmed/id/7528237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-1-25
pubmed:abstractText
A studies of cytotoxic cells in athymic nude mice demonstrate higher cytotoxic activity of NK cells and macrophages than in their euthymic counterparts. The higher level of endogenous cytotoxic activity can be considered as complementary to the deficiency or lack of thymus dependent T lymphocytes and their functions. However, with increased age of mice some T lymphocytes and their functions can be demonstrated. By stimulation of splenocytes and lymph node cells in vitro with IL-2 or anti CD3 antibody cytotoxic activity towards P-815 (NK resistant, LAK sensitive) target cells can be generated. There exist data, which indicate that the cytotoxic activity is exerted by extrathymic pre-T lymphocytes with TcR gamma delta antigenic phenotype. The differences in transplantability of human tumors in athymic nude mice cannot be explained by defect in antigen recognition and in immune response of athymic nude mice, recipients of the xenografted material. The biological relevance in vivo of high endogenous cytotoxicity of NK cells observed in many strains of athymic nude mice remains obscure. The availability of new immunodeficient mouse models, e.g. scid mice deficient in B and T lymphocytes and with low level of NK cells, in which not only xenografted human tumor grow but human lymphoid cell can be transplanted as well, opens new and broader experimental possibilities, in which new preclinical immunotherapeutical approaches can be applied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0892-3973
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-46
pubmed:dateRevised
2009-5-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Cytotoxic cells in immunodeficient athymic mice.
pubmed:affiliation
Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
pubmed:publicationType
Journal Article, Review