Linked Life Data

7146571

Source:http://linkedlifedata.com/resource/pubmed/id/7146571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-1-19
pubmed:abstractText
Some features of energy metabolism in two strains of Ehrlich ascites tumor cells are presented in this paper. A correlation between malignancy and activity of aerobic glycolysis was observed. In the Roma strain, ammonium ions (1-10 mM) enhance the aerobic glycolysis and the Crabtree effect induced by 5 mM glucose. In spite of the activation of glycolysis, the total amount of pyruvate and lactate decreased in the presence of ammonium, because a drain of pyruvate takes place through the pyruvate dehydrogenase complex. Ammonium ions fail to modify the Crabtree effect or the aerobic glycolysis in CBM strain. In these cells, NH4+ did not affect the pyruvate and lactate produced from glucose. It is suggested that ammonium effect on the aerobic glycolysis in Roma strain could be adventageous for tumor growth, because there is an increase in the availability of carbon skeleton from glucose to account for the assimilation of NH4+ and consequently for the synthesis of aminoacids.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0034-9402
pubmed:author
pubmed:issnType
Print
pubmed:volume
38 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Effect of ammonia on the Crabtree effect of 2 strains of Ehrlich ascites tumor].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract