Linked Life Data

6956763

Source:http://linkedlifedata.com/resource/pubmed/id/6956763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-3
pubmed:abstractText
Outbred Swiss Cox mice of both sexes were chronically exposed to urethan added to their drinking water at levels of 0.02--0.10% by weight. The number and sizes of lung adenomas that developed as a result were monitored as functions of time and dose rate (DR). The relationship between dose per unit time, or DR, and time (t1) needed for the development of a mean of one observable tumor per mouse was: DR x tn1 = k, where K and n are constants. The value of n was 2.75. This value could be largely accounted for by the DR-independent tumor growth time, although an increase in the number of target cells at higher urethan dose rates may also be a factor in the relationship between DR and t1. Examination of the relationships between cumulative incidence and DR and between cumulative incidence and adenoma induction time suggests that urethan acts at one stage of a two-stage mechanism in the induction of mouse lung adenomas.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
859-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Relationship between urethan dose rate and adenoma latency: relevance of tumor growth rate and target cell number.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.