Linked Life Data

6737433

Source:http://linkedlifedata.com/resource/pubmed/id/6737433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1984-8-7
pubmed:abstractText
A common three-dimensional receptor model has been formulated for six different classes of rat liver dihydrofolate reductase inhibits using the distance geometry approach. Altogether, 62 molecules of five different classes were used to generate the receptor model, which has 11 attractive site points and 5 repulsive ones. It gave a fit having a correlation coefficient of 0.949 and root mean square (rms) deviation of 0.527. The attractive site points of the model closely correspond to the one we reported earlier. The model successfully predicted the biological data of 33 molecules of 5 different classes, one molecule of which was a member of a new class not included in the original data set. Guidelines are put forth for the synthesis of improved inhibitors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
901-14
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't