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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1985-4-1
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pubmed:abstractText |
Of 75 patients with HBsAg negative chronic active hepatitis (CAH), 28 had antinuclear antibodies in their serum. We have tested these patients' sera for serum antibodies against double stranded (native) DNA (anti-ds-DNA), by immunofluorescence with Crithidia luciliae as substrate. They were found in 14 patients (50 p. 100). Thirteen of the patients with anti-ds-DNA and 11 of those without were female; the mean ages were 64 +/- 16 and 56 +/- 19 years, respectively. The clinical and biological signs seemed to be more severe in patients with anti-ds-DNA than in those without. Liver histological activity and frequency of cirrhosis (about 50 p. 100) were similar in patients with or without anti-ds-DNA. Ten of the 14 patients with anti-ds-DNA had been given hepatotoxic drugs whereas only 2 patients lacking these antibodies had taken a hepatotoxic drug (p less than 0.01). In subjects with anti-ds-DNA, clometacin was the most common hepatotoxic drug, taken alone in 5 patients or together with other hepatotoxic drugs in 3 subjects. Only 4 of the patients with anti-ds-DNA displayed symptoms of systemic lupus erythematosus and two of these subjects took a hepatotoxic drug. In our experience, serum anti-ds-DNA were frequently found in patients with CAH and antinuclear antibodies; in this group CAH was often associated with hepatotoxic drugs, especially clometacin. Thus, the presence of anti-ds-DNA in sera of patients with HBsAg negative CAH may be an indication of drug-induced liver damage.
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0399-8320
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
833-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:6396151-Antibodies, Antinuclear,
pubmed-meshheading:6396151-DNA,
pubmed-meshheading:6396151-Drug-Induced Liver Injury,
pubmed-meshheading:6396151-Drug-Induced Liver Injury, Chronic,
pubmed-meshheading:6396151-Female,
pubmed-meshheading:6396151-Fluorescent Antibody Technique,
pubmed-meshheading:6396151-Hepatitis, Chronic,
pubmed-meshheading:6396151-Humans,
pubmed-meshheading:6396151-Indoleacetic Acids,
pubmed-meshheading:6396151-Male,
pubmed-meshheading:6396151-Time Factors
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pubmed:year |
1984
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pubmed:articleTitle |
[Chronic active hepatitis associated with anti-native DNA antibodies: incidence of drug etiology].
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pubmed:publicationType |
Journal Article,
English Abstract
|