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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1984-11-5
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pubmed:abstractText |
Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the amides were found to be potent antiarrhythmic agents that possessed low parasympatholytic activity. All of the compounds appear to act by a class I mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1347-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6384519-Amides,
pubmed-meshheading:6384519-Animals,
pubmed-meshheading:6384519-Anti-Arrhythmia Agents,
pubmed-meshheading:6384519-Chemical Phenomena,
pubmed-meshheading:6384519-Chemistry,
pubmed-meshheading:6384519-Dogs,
pubmed-meshheading:6384519-Electric Stimulation,
pubmed-meshheading:6384519-Guinea Pigs,
pubmed-meshheading:6384519-Heart Rate,
pubmed-meshheading:6384519-Ileum,
pubmed-meshheading:6384519-Indicators and Reagents,
pubmed-meshheading:6384519-Magnetic Resonance Spectroscopy,
pubmed-meshheading:6384519-Male,
pubmed-meshheading:6384519-Methacholine Chloride,
pubmed-meshheading:6384519-Methacholine Compounds,
pubmed-meshheading:6384519-Muscle Contraction,
pubmed-meshheading:6384519-Parasympatholytics,
pubmed-meshheading:6384519-Structure-Activity Relationship
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pubmed:year |
1984
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pubmed:articleTitle |
Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides.
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pubmed:publicationType |
Journal Article,
Comparative Study
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