| pubmed-article:6343484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6343484 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6343484 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6343484 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6343484 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:6343484 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:6343484 | lifeskim:mentions | umls-concept:C0002131 | lld:lifeskim |
| pubmed-article:6343484 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6343484 | pubmed:dateCreated | 1983-7-8 | lld:pubmed |
| pubmed-article:6343484 | pubmed:abstractText | A panel of monoclonal antibodies with specificity for rat T cell alloantigens was prepared by somatic cell hybridization with the use of spleen cells from either BH (ART-1b, 2b) or NBR (ART-1b, 2a) rats immunized with LEW (ART-1a, 2a) thymus, spleen, or lymph node cells. Comparison of the antibodies resulted in three distinct patterns of complement-mediated cytotoxicity. Further comparison of four representative hybridoma antibodies with antisera having specificity for ART antigens by indirect immunofluorescence demonstrated that two of the three patterns corresponded to anti-ART-1a and anti-ART-2a specificities. The patterns of binding of the anti-ART hybridomas were shown to be different from those produced by mouse monoclonal antibodies having anti-leukocyte-common (L-C) or anti-Thy-1.1 activities as well as antibodies produced by the monoclonal W3/25, which detect a subpopulation of T lymphocytes. Functional studies performed in vitro with cells fractionated by treatment with the monoclonal anti-ART antibodies and complement showed the ART-1 determinant recognized by the hybridoma products BC 84A or BY 12.3 is expressed by mature cytolytic T lymphocytes (CTL) and by cells involved in the generation of CTL during MLR, but not plaque-forming cells. Together, the data suggest the antibodies BC 84A and BY 12.3 can be used to define rat T cell populations. To date, the functional significance of cell populations recognized by monoclonal antibodies having anti-ART-2a or anti-ART-3-like activities has not been determined. | lld:pubmed |
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| pubmed-article:6343484 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6343484 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6343484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6343484 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6343484 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6343484 | pubmed:author | pubmed-author:FitchF WFW | lld:pubmed |
| pubmed-article:6343484 | pubmed:author | pubmed-author:LubaroffD MDM | lld:pubmed |
| pubmed-article:6343484 | pubmed:author | pubmed-author:GreinerD LDL | lld:pubmed |
| pubmed-article:6343484 | pubmed:author | pubmed-author:IZTT | lld:pubmed |
| pubmed-article:6343484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6343484 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:6343484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6343484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6343484 | pubmed:pagination | 2798-803 | lld:pubmed |
| pubmed-article:6343484 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:6343484 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6343484 | pubmed:articleTitle | Characterization of monoclonal antibodies that define rat T cell alloantigens. | lld:pubmed |
| pubmed-article:6343484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6343484 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6343484 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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