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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-8-8
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pubmed:abstractText |
Administration of pertussis toxin to hamsters abolishes the alpha 2-adrenergic inhibition of adenylate cyclase in their adipocytes. The toxin did not modify the number of adipocyte alpha 2-adrenoceptors or their affinity for antagonists. In contrast, the affinity for agonists was significantly diminished in adipocyte membranes obtained from pertussis toxin-treated hamsters as compared to the controls. This decrease in affinity was due to a significant diminution in the proportion of sites displaying the high-affinity state for agonists. It is concluded that pertussis toxin induces a shift in the proportion of sites in high- and low-affinity states. for agonists towards the low-affinity conformation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroergotoxine,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylyl Imidodiphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6329826-Adenylate Cyclase,
pubmed-meshheading:6329826-Adenylate Cyclase Toxin,
pubmed-meshheading:6329826-Adipose Tissue,
pubmed-meshheading:6329826-Adrenocorticotropic Hormone,
pubmed-meshheading:6329826-Animals,
pubmed-meshheading:6329826-Bacterial Toxins,
pubmed-meshheading:6329826-Binding, Competitive,
pubmed-meshheading:6329826-Cricetinae,
pubmed-meshheading:6329826-Dihydroergotoxine,
pubmed-meshheading:6329826-Epinephrine,
pubmed-meshheading:6329826-Guanylyl Imidodiphosphate,
pubmed-meshheading:6329826-Isoproterenol,
pubmed-meshheading:6329826-Male,
pubmed-meshheading:6329826-Mesocricetus,
pubmed-meshheading:6329826-Pertussis Toxin,
pubmed-meshheading:6329826-Receptors, Adrenergic, alpha,
pubmed-meshheading:6329826-Virulence Factors, Bordetella
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pubmed:year |
1984
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pubmed:articleTitle |
Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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