| pubmed-article:6208306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6208306 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:6208306 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6208306 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6208306 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:6208306 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:6208306 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:6208306 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6208306 | pubmed:dateCreated | 1984-12-7 | lld:pubmed |
| pubmed-article:6208306 | pubmed:abstractText | The association between T3 and the T cell antigen receptor was examined using the T3 bearing T cell leukemic line Jurkat. A monoclonal antibody, C305, was produced, which reacted with idiotypic-like determinants expressed on Jurkat. The molecule with which this antibody reacted was a disulfide-linked heterodimer of 90 kD, composed of polypeptides of 42 and 54 kD. Thus, C305 reacted with a molecule with characteristics of the putative T cell antigen receptor described by others. A series of mutants of Jurkat, induced with ethyl methane sulfonate or radiation, was selected for T3 or antigen receptor negativity. In every instance, there was a concomitant loss of both T3 and the antigen receptor as assessed by quantitative absorption, indirect immunofluorescence, and antibody plus complement-mediated cytotoxicity. The absence of antigen receptor molecules was confirmed on diagonal gels, excluding the possibility that conformational changes of the antigen receptor on such T3-negative mutants were responsible for the failure of such mutants to react with C305. Moreover, in a mutant that expressed a marked decrease in the level of T3 expression, there was a comparable decrease in the expression of antigen receptor determinants. These results suggest that there is an obligate requirement for the coexpression of T3 and the T cell antigen receptor. Furthermore, attempts to activate such mutants with the lectin phytohemagglutinin suggested that the expression of T3 and/or the antigen receptor was required for activation of these cells. | lld:pubmed |
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| pubmed-article:6208306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6208306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6208306 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6208306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6208306 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6208306 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6208306 | pubmed:author | pubmed-author:WeiseWW | lld:pubmed |
| pubmed-article:6208306 | pubmed:author | pubmed-author:StoboJ DJD | lld:pubmed |
| pubmed-article:6208306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6208306 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6208306 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:6208306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6208306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6208306 | pubmed:pagination | 1284-99 | lld:pubmed |
| pubmed-article:6208306 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6208306 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6208306 | pubmed:articleTitle | Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. | lld:pubmed |
| pubmed-article:6208306 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6208306 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6208306 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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