Linked Life Data

3731048

Source:http://linkedlifedata.com/resource/pubmed/id/3731048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-9-17
pubmed:abstractText
The indirect mutagen cyclophosphamide (CP) is known to induce chromosomal aberrations in human lymphocyte cultures only after exogenous metabolic activation. We document here that lymphocytes from five patients with Fanconi's anemia (FA) exhibited extensive chromosomal breakage when cultured in the continuous presence of 1 mM CP without deliberate activation of the drug, whereas, cultures from healthy subjects were not significantly susceptible to breakage under these conditions. CP exposure also enhanced the frequency of sister chromatid exchanges (SCE), but to similar extents in control and FA subjects, suggesting that there is a similar low level of CP metabolism in FA and normal lymphocytes. The direct clastogenic effect of nonactivated CP as demonstrated here in FA lymphocyte cultures may be of value in screening for possible hypersensitivity in patients considered for CP therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-45
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Clastogenicity of cyclophosphamide in Fanconi's anemia lymphocytes without exogenous metabolic activation.
pubmed:publicationType
Journal Article