rdf:type |
|
lifeskim:mentions |
umls-concept:C0002154,
umls-concept:C0007009,
umls-concept:C0009148,
umls-concept:C0010106,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0178499,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0872086,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1514468,
umls-concept:C1963578
|
pubmed:issue |
10
|
pubmed:dateCreated |
1988-2-8
|
pubmed:abstractText |
A pyrolytic carbon coating was applied to F-75 chromium-cobalt-molybdenum alloy in an effort to reduce the release of corrosion products in vivo. After intramuscular implantation in the rat, a complex pattern of serum and urine concentration elevations of chromium, cobalt, and nickel was seen. The carbon-coated implants released more chromium and cobalt than uncoated controls, as seen by significantly elevated metal concentrations in serum and urine. Animals receiving carbon-coated implants showed a high rate of recurrent implant site inflammation. Neoplastic infiltration of 24 animals with coated implants, but not in any of the 16 animals which received either uncoated F-75 microsphere or poly(ethylene) particulate implants.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0021-9304
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1213-30
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3693385-Alloys,
pubmed-meshheading:3693385-Animals,
pubmed-meshheading:3693385-Biocompatible Materials,
pubmed-meshheading:3693385-Body Weight,
pubmed-meshheading:3693385-Carbon,
pubmed-meshheading:3693385-Chromium,
pubmed-meshheading:3693385-Cobalt,
pubmed-meshheading:3693385-Corrosion,
pubmed-meshheading:3693385-Lung,
pubmed-meshheading:3693385-Male,
pubmed-meshheading:3693385-Microspheres,
pubmed-meshheading:3693385-Molybdenum,
pubmed-meshheading:3693385-Rats,
pubmed-meshheading:3693385-Rats, Inbred Strains
|
pubmed:year |
1987
|
pubmed:articleTitle |
Release of corrosion products by F-75 cobalt base alloy in the rat. III: Effects of a carbon surface coating.
|
pubmed:affiliation |
Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia 19104.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|