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pubmed-article:3503759pubmed:abstractTextThe possible genetic predisposition to abdominal aortic aneurysm was investigated by recording the family history from 60 consecutive patients presenting for aneurysm repair. Twenty patients, age 63.2 +/- 9.3 years, had at least one first degree relative with abdominal aortic aneurysm. Thirty six patients, age 69.6 +/- 6.3 years, knew of no aortic aneurysm amongst first degree relatives and four patients could not give a full family history. A total of 25 among 320 first degree relatives (8%) or 14 amongst 192 siblings (7%) had an abdominal aortic aneurysm. Both the younger age of presentation (P less than 0.01) and the concentration of women amongst those with a positive family history argue for multifactorial inheritance of abdominal aortic aneurysm, with the genetic component calculated as approximately 70%. These same factors suggest that it might be worthwhile screening for aneurysmal disease the sibling smokers of female and younger male probands.lld:pubmed
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pubmed-article:3503759pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:3503759pubmed:articleTitleMultifactorial inheritance of abdominal aortic aneurysm.lld:pubmed
pubmed-article:3503759pubmed:affiliationDepartment of Surgery, Charing Cross and Westminster Medical School, London, UK.lld:pubmed
pubmed-article:3503759pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3503759pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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