Linked Life Data

3157841

Source:http://linkedlifedata.com/resource/pubmed/id/3157841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-6-7
pubmed:abstractText
The antiviral substance PFA (trisodium phosphonoformate) was administered I.V. and P.O. to six young female Beagle dogs, and to white New Zealand rabbits using a randomized crossover design. The pharmacokinetics of PFA was determined from the I.V. concentration-time data by polyexponential curve fitting and by a compartment model independent analysis. In dogs the I.V. data were best fit to three exponential terms. The terminal half-life ranged from 2.6 to 7.9 hours (mean 4.03 h +/- 2.04 S.D.). The mean volumes of distribution for the central compartment, Vc, at steady state, Vss and during the terminal phase, Vz, were 0.15, 0.65 and 1.32 L/kg, respectively. The two methods for generation of pharmacokinetic parameters resulted in practically identical values. After extravascular administration, the concentration-time data were subjected to compartment model independent analysis. The mean absolute bioavailability was 10% after P.O. administration. In rabbits, 11 out of 12 I.V. data sets were best fit to two exponential terms; one set was best fit to 3 exponential terms. The terminal half-life ranged from 1.47 to 4.15 hours (mean 2.18 h +/- 0.87 S.D.). The mean volumes of distribution for Vc, Vss and Vz were 0.32, 0.45 and 0.96 L/kg, respectively. After P.O. dosing the t 1/2 was about 4.4 h and the apparent volume of distribution about 1.2 L/kg. The mean absolute bioavailability after P.O. administration was 95%. The difference in P.O. bioavailability between dog and rabbit may be due to intragastric pH differences between the two species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Pharmacokinetics of PFA (trisodium phosphonoformate) after i.v. and p.o. administration to beagle dogs and rabbits.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't