Linked Life Data

3147191

Source:http://linkedlifedata.com/resource/pubmed/id/3147191

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-4-6
pubmed:abstractText
In the period 1963-1974, 82 monks and 48 nuns from five Dutch and Belgian Trappist monasteries each participated in two or more out of nine different trials designed to test the effect of 58 different fat-modified diets on serum cholesterol. We analysed these data to quantify the extent to which healthy, normolipaemic subjects differ in the responsiveness of their serum cholesterol to a change in dietary fatty acid composition. Statistically significant between-person variance components (SD2p) were found in the serum cholesterol responses for the whole group (SD2p = [0.20 mmol l-1]2), for the men (SD2p = [0.24 mmol l-1]2) and for those women who participated in three or more trials (SD2p = [0.14 mmol l-1]2). The between-person variation (expressed as SD) was on average only half as large as the within-person variation in response when the same subject was challenged repeatedly. It is concluded that medically significant differences in responsiveness to fat-modified diets exist in both men and women. However, few subjects fail entirely to respond to a change in dietary fatty acid composition. In addition, the large within-subject variability makes it difficult to identify hypo- and hyperresponders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2972
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
644-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Differences in individual responsiveness of serum cholesterol to fat-modified diets in man.
pubmed:affiliation
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial