| pubmed-article:3010634 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C1548779 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C1947902 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C2827499 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C2347822 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:3010634 | lifeskim:mentions | umls-concept:C1167624 | lld:lifeskim |
| pubmed-article:3010634 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3010634 | pubmed:dateCreated | 1986-6-6 | lld:pubmed |
| pubmed-article:3010634 | pubmed:abstractText | The photoaffinity probe 125I-APDQ has been used to characterize alpha 1-receptor peptides in the cod and rat brains. In the cod brain a major specific peptide of Mr = 68,000 could be covalently labeled by 125I-APDQ as revealed by SDS-PAGE. In the rat brain a specific peptide with Mr = 77,000 was instead labeled. When a number of adrenergic agonists and antagonists were tested for their ability to protect the labeling by 125I-APDQ their potencies were those expected for alpha 1-receptors in both species. The ligand binding peptide in the cod brain also distinguished between stereoisomers of epinephrine as expected for a physiological receptor. However, there was a distinct difference between the cod and rat alpha 1-receptor in that the beta-agonist 1-isoprenaline was equipotent to 1-norepinephrine in the cod whereas it was less potent in the rat. The protecting ability of the tested agents were also matched by their ability to displace the alpha 1-adrenergic ligand 3H-prazosin from alpha 1-receptor binding sites in brain membranes from both species. Thus, the codfish alpha 1-receptor seems to be different from mammalian alpha 1-receptors both structurally and pharmacologically. | lld:pubmed |
| pubmed-article:3010634 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3010634 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3010634 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3010634 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3010634 | pubmed:issn | 0001-6683 | lld:pubmed |
| pubmed-article:3010634 | pubmed:author | pubmed-author:WikbergJ EJE | lld:pubmed |
| pubmed-article:3010634 | pubmed:author | pubmed-author:BergströmAA | lld:pubmed |
| pubmed-article:3010634 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3010634 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:3010634 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3010634 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3010634 | pubmed:pagination | 148-55 | lld:pubmed |
| pubmed-article:3010634 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
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| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
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| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:meshHeading | pubmed-meshheading:3010634-... | lld:pubmed |
| pubmed-article:3010634 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3010634 | pubmed:articleTitle | Structural and pharmacological differences between codfish and rat brain alpha 1-adrenergic receptors revealed by photoaffinity labeling with 125I-APDQ. | lld:pubmed |
| pubmed-article:3010634 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3010634 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3010634 | lld:pubmed |
