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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-5-17
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pubmed:abstractText |
Antagonists of neuronal excitation induced by dicarboxylic amino acids were tested in genetically spastic rats of the Han-Wistar strain. These animals exhibit an increased muscle tone which can be measured as a spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Compounds that block excitation due to N-methyl-D-aspartic acid reduced the spontaneous activity measured in the electromyogram in a dose-related manner. The most potent compounds, 2-amino-7-phosphonoheptanoic and kynurenic acids were effective muscle relaxants when given either intraperitoneally or intracerebroventricularly. 2-Amino-5-phosphonopentanoic acid possessed much weaker muscle relaxant activity, while L-glutamic acid diethylester was inactive by either route. The results suggest that blockade of N-methyl-D-aspartic acid receptors results in a myorelaxant effect. Specific antagonists of excitation at N-methyl-D-aspartic acid receptors may provide a new class of muscle relaxants.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-7-phosphonoheptanoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Kynurenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Relaxants, Central,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Valine,
http://linkedlifedata.com/resource/pubmed/chemical/glutamic acid diethyl ester
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2858836-2-Amino-5-phosphonovalerate,
pubmed-meshheading:2858836-Amino Acids,
pubmed-meshheading:2858836-Animals,
pubmed-meshheading:2858836-Aspartic Acid,
pubmed-meshheading:2858836-Female,
pubmed-meshheading:2858836-Glutamates,
pubmed-meshheading:2858836-Kynurenic Acid,
pubmed-meshheading:2858836-Male,
pubmed-meshheading:2858836-Muscle Relaxants, Central,
pubmed-meshheading:2858836-Muscle Spasticity,
pubmed-meshheading:2858836-N-Methylaspartate,
pubmed-meshheading:2858836-Rats,
pubmed-meshheading:2858836-Rats, Inbred Strains,
pubmed-meshheading:2858836-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:2858836-Receptors, Neurotransmitter,
pubmed-meshheading:2858836-Valine
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pubmed:year |
1985
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pubmed:articleTitle |
Muscle relaxant action of excitatory amino acid antagonists.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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